ol052922i_si_001.pdf (2.21 MB)

Expedient Synthesis of (±)-Bipinnatin J

Download (2.21 MB)
journal contribution
posted on 19.01.2006, 00:00 by Paul A. Roethle, Dirk Trauner
A nine-step, stereoselective synthesis of bipinnatin J is described, which features a ruthenium-catalyzed Alder-ene reaction, a Stille cross coupling, and an intramolecular Nozaki−Hiyama−Kishi allylation as key steps. The biosynthetic relationship between bipinnatin J and complex polycyclic diterpenes isolated from gorgonian corals is discussed.