jo0616052_si_001.pdf (1.41 MB)
Download file

Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine

Download (1.41 MB)
journal contribution
posted on 27.10.2006, 00:00 by Florence F. Wagner, Daniel L. Comins
Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.