American Chemical Society
Browse

Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine

Download (1.41 MB)
journal contribution
posted on 2006-10-27, 00:00 authored by Florence F. Wagner, Daniel L. Comins
Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.

History

Usage metrics

    The Journal of Organic Chemistry

    Categories

    Keywords

    nicotineagentSIBNatural NicotineAltiniclineSynthesiExpedientregioselective substitutionpyridine ring

    Licence

    CC BY-NC 4.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC