American Chemical Society
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Executing a Series of Zinc(II) Complexes of Homologous Schiff Base Ligands for a Comparative Analysis on Hydrolytic, Antioxidant, and Antibacterial Activities

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journal contribution
posted on 2020-06-12, 13:04 authored by Tania Chowdhury, Sanchari Dasgupta, Somanjana Khatua, Krishnendu Acharya, Debasis Das
Six zinc­(II) complexes, namely, [Zn­(HL1H)­Cl2] (1), [Zn­(HL1H)­Br2] (2), [Zn2(HL1H)2(OH)­I2]·I (3), [Zn­(HL2)­Cl] (4), [Zn2(HL2)­Br3] (5), and [Zn­(HL2)­I] (6) have been manufactured by using two homologous Schiff base ligands H2L1 and H2L2 for the purpose of perlustrating their phosphatase-like activity, antioxidant activity, and antibacterial activity. Complexes 1, 2, 4, and 5 have been reported earlier by us, whereas complexes 3 and 6 have been synthesized and structurally characterized by regular physicochemical methods The hydrolytic property of the six complexes has been evaluated by checking the hydrolysis of the P–O bond of a widely used substrate, namely, disodium salt of (para-nitrophenyl)­phosphate (PNPP) in 97.5% (v/v) mixture of N,N-dimethylformamide and water (DMF–water). Complexes 2–5 have profound efficiency toward hydrolysis of phosphate ester bonds, and complexes 1 and 6 were noted to be inactive toward hydrolysis. Complex 3 displayed the highest efficacy among the six complexes. Additionally, antioxidant and antibacterial activities of the complexes were studied thoroughly. A detailed study of their antioxidant property revealed that complex 3 manifested superior radical scavenging activity, thus exhibiting the highest antioxidant property. The antibacterial activity was tested using four investigating bacteria, specifically Listeria monocytogenes ATCC19111, Staphylococcus aureus ATCC 700699, Salmonella typhimurium ATCC 23564, and Escherichia coli ATCC 25922 by determining minimum inhibitory concentration (MIC) values using the microdilution method. Here as well, complex 3 exhibited the highest activity to both Gram positive and Gram negative bacteria. The chemistry behind these experimental findings has been manifested by shedding light upon the structural features of the complexes. The suitable choice of ligand H2L1 where one methylene group is less than its homologous ligand and metal precursor (ZnI2) imparts a unique hydroxo-bridged molecular geometry and 2D hydrogen bonding network which in turn probably enhances the hydrolytic and biological activities of complex 3.