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Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems

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journal contribution
posted on 14.10.2016, 00:00 by Gavin Hazell, Thomas Arnold, Robert D. Barker, Luke A. Clifton, Nina-Juliane Steinke, Cecilia Tognoloni, Karen J. Edler
Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid–liquid or air–liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.