Eutectic Solvent-Mediated Synthesis of NiFe-LDH/Sulfur-Doped Carbon Nitride Arrays: Investigation of Electrocatalytic Activity for the Dimetridazole Sensor in Human Sustenance

Pharmaceutical contamination is an emerging environmental concern that threatens global health and impacts every hemisphere of existence. The extensive exploitation and unregulated release of these chemical pollutants challenge environmental sustainability and call for their immediate detection and remediation. This study discusses the electrochemical determination of the antiprotozoal drug (dimetridazole), which is banned in numerous places owing to suspicions of it being carcinogenic, using a 2D/2D heterojunction. The detrimental outcomes of the drug demonstrate the significance of its effective detection and the development of suitable materials for the sensing application. The deep eutectic solvent-based fabrication of Ni–Fe layered double hydroxide nanosheets/sulfur-doped graphitic carbon nitride heterostructure features the green and ecologically benign synthesis of the compound with remarkable properties. The conjunction of hierarchical structures offers synergistic quantum confinement effects and confines charge carriers promoting abundant active sites. The improved electrocatalytic activity of the proposed drug sensor reinforces its perspectives by exhibiting higher sensitivity, wide linear-range responses (0.008–110.77 μM), a lower limit of detection (1.6 nM), appreciable stability, and higher selectivity. Analysis of real samples with the developed electrocatalyst underpins its practical applications in the real world. The development of superior architectures with lower energy requirements and minimal byproducts marks the superior characteristics of the synthesis methodology within the guidelines of green chemistry.