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Eucalyptusdimers A–C, Dimeric Phloroglucinol–Phellandrene Meroterpenoids from Eucalyptus robusta

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journal contribution
posted on 08.08.2018, 15:18 authored by Xu-Jie Qin, Mi-Yan Feng, Hui Liu, Wei Ni, Tyler Rauwolf, John A. Porco, Huan Yan, Li He, Hai-Yang Liu
Eucalyptusdimers A–C, three dimeric phellandrene-derived meroterpenoids featuring an unprecedented, fused skeleton between two phellandrene and two acylphloroglucinol subunits, along with one biogenetically related intermediate, (±)-eucalyprobusone A, were isolated from the fruits of Eucalyptus robusta. Their structures and absolute configurations were elucidated using spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. The isolated meroterpenoids were evaluated for their anti-inflammatory, acetylcholinesterase inhibitory, and protein tyrosine phosphatase 1B inhibitory effects.