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Download fileEucalyptusdimers A–C, Dimeric Phloroglucinol–Phellandrene Meroterpenoids from Eucalyptus robusta
journal contribution
posted on 2018-08-08, 15:18 authored by Xu-Jie Qin, Mi-Yan Feng, Hui Liu, Wei Ni, Tyler Rauwolf, John A. Porco, Huan Yan, Li He, Hai-Yang LiuEucalyptusdimers
A–C, three dimeric phellandrene-derived
meroterpenoids featuring an unprecedented, fused skeleton between
two phellandrene and two acylphloroglucinol subunits, along with one
biogenetically related intermediate, (±)-eucalyprobusone A, were
isolated from the fruits of Eucalyptus robusta. Their
structures and absolute configurations were elucidated using spectroscopic
data, X-ray crystallography, and electronic circular dichroism analysis.
The isolated meroterpenoids were evaluated for their anti-inflammatory,
acetylcholinesterase inhibitory, and protein tyrosine phosphatase
1B inhibitory effects.
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skeletoneucalyprobusoneprotein tyrosine phosphatase 1 Banti-inflammatoryEucalyptus robustadichroism analysisspectroscopic datadimeric phellandrene-derived meroterpenoidsEucalyptus robusta EucalyptusdimersPhloroglucinolacylphloroglucinol subunitsDimericX-ray crystallographyMeroterpenoidconfigurationacetylcholinesterasebiogenetically