Enzymatic Removal of Carboxyl Protecting Groups. 2. Cleavage of the Benzyl and Methyl Moieties
journal contributionposted on 2005-10-28, 00:00 authored by Efrosini Barbayianni, Irene Fotakopoulou, Marlen Schmidt, Violetta Constantinou-Kokotou, Uwe T. Bornscheuer, George Kokotos
Enzymes are versatile reagents for the efficient removal of methyl and benzyl protecting groups. An esterase from Bacillus subtilis (BS2) and a lipase from Candida antarctica (CAL-A) allow a mild and selective removal of these moieties in high yields without affecting other functional groups.