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Environmentally Friendly Protocol for 2,3-Difunctionlization of Indole Derivatives

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journal contribution
posted on 27.07.2020, 15:35 by Wen-Wu Sun, Na Chen, Ting-Ting Wei, Guo-Jing You, Hao Yang, Ji-Kai Liu, Bin Wu
Environmentally friendly and highly regioselective C-3 dichlorination and C-2 oxidation of N-substituted indoles have been established using NaCl as a chlorine source and H2O as an oxygen source. A series of 3,3-dichloro-2-oxindoles were obtained in moderate to excellent yields. The gram-scale synthesis and derivatization reaction were explored. The possible mechanism for this reaction was elucidated.