posted on 2024-03-12, 22:16authored byJingcheng Zheng, Weiwei Zhang, Yun Huang, Jiwei Shao, Malik Saddam Khan, Yuwu Chi
Recently emerging perovskite nanocrystals (PNCs) are
very attractive
fluorescence nanomaterials due to their very narrow emission peak,
tunable wavelength, and extremely high quantum yield, but their chemosensing, biosensing and bioimaging applications suffer
from the poor stability of ordinary PNCs in aqueous media, especially
in biological matrices. Recently developed water-stable 2D CsPb2Br5-encapsulated 3D CsPbBr3 PNCs (i.e.,
CsPbBr3/CsPb2Br5 PNCs) show extremely
stable light emission in pure water, but their fluorescence is seriously
quenched in aqueous media containing biological molecules due to their
chemical reactions. In this work, we used a facile method to encapsulate
pure water-stable CsPbBr3/CsPb2Br5 PNCs in water with SiO2 and polyethylene glycol hexadecyl
ether (Brij58) into a new kind of biological environment-stable PNCs
(CsPbBr3/CsPb2Br5@SiO2–Brij58). The synthesis of the target PNCs can be accomplished
in a fast, easy, and green way. The obtained CsPbBr3/CsPb2Br5@SiO2–Brij58 PNCs maintain
strong fluorescence emission for a long time, all in pH 7.4 PBS, BSA,
and minimum essential medium, exhibiting excellent biological environment
stability. Moreover, the developed biological environment-stable PNCs
show good biocompatibility and have been successfully used in cell
imaging. Overall, the work provides an easy, low-cost, and efficient
application of PNCs in bioimaging.