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Download fileEncapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes
journal contribution
posted on 01.06.2018, 12:53 authored by Sieun Chae, Dahee Kim, Kyung-jin Lee, Dasol Lee, Young-O Kim, Yong Chae Jung, Sang Dal Rhee, Kwang Rok Kim, Jeong-O Lee, Sunjoo Ahn, Byumseok KohThe
topoisomerase I inhibitors SN-38 and camptothecin (CPT) have
shown potent anticancer activity, but water insolubility and metabolic
instability limits their clinical application. Utilizing carbon nanotubes
as a protective shell for water-insoluble SN-38 and CPT while maintaining
compatibility with aqueous media via a carboxylic acid-functionalized
surface can thus be a strategy to overcome this limitation. Through
hydrophobic–hydrophobic interactions, SN-38 and CPT were successfully
encapsulated in carboxylic acid functionalized single-walled carbon
nanotubes and dispersed in water. The resulting cell proliferation
inhibition and drug distribution profile inside the cells suggest
that these drug-encapsulated carbon nanotubes can serve as a promising
delivery strategy for water-insoluble anticancer drugs.
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water insolubilitycarboxylic acid functionalized single-walled carbon nanotubesdrug-encapsulated carbon nanotubesCPTSN -38water-insoluble SN -38cell proliferation inhibitionFunctionalized Carbon Nanotubesinhibitors SN -38Utilizing carbon nanotubesdelivery strategydrug distribution profileinstability limitscarboxylic acid-functionalized surfacewater-insoluble anticancer drugsEnhanced Deliveryanticancer activity