posted on 2024-01-08, 16:40authored byLianshan Li, Xuejun Zhao, Kunming Hu, Weiye Xu, Minghua Wang, Hongjie Wang
Phenylpyrazole
insecticides are widely used as chiral pesticides.
However, the enantioselective toxicity and potential endocrine-disrupting
effects of these insecticides on aquatic organisms remain unclear.
Herein, the enantioselective toxicity and potential endocrine-disrupting
effects of flufiprole and ethiprole were investigated by using zebrafish
embryos/larvae as a model. The acute toxicity of R-flufiprole and R-ethiprole toward zebrafish embryos
and larvae was 1.8–3.1-fold higher than that of the S-configuration. Additionally, R-flufiprole
and R-ethiprole had a greater effect on the expression
of genes related to the hypothalamus–pituitary–gonad
axis in zebrafish compared with the S-configuration. Nevertheless,
both S-flufiprole and S-ethiprole
exhibited a greater interference effect on the expression of genes
related to the hypothalamus–pituitary–thyroid axis and
a greater teratogenic effect on zebrafish than the R-configuration.
Thus, this study demonstrates that both flufiprole and ethiprole exhibit
enantioselective acute toxicity and developmental toxicity toward
zebrafish. Furthermore, those pesticides potentially possess enantioselective
endocrine-disrupting effects.