Enantioselective Total Synthesis of (−)-α-Kainic Acid
journal contributionposted on 05.03.2010, 00:00 by Andreas Farwick, Günter Helmchen
An enantioselective total synthesis of (−)-α-kainic acid is described. Key steps are an Ir-catalyzed allylic amination with a propargylic amine to provide an enyne and a diastereoselective intramolecular Pauson−Khand reaction. Subsequent steps involve a Baeyer−Villiger reaction, reduction of the resulting lactone, and direct Jones oxidation of a silyl ether.