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Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization

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journal contribution
posted on 17.12.2015, 07:14 by Anna Homs, Michael E. Muratore, Antonio M. Echavarren
The first enantioselective total synthesis of (−)-nardoaristolone B is accomplished by the implementation of an enantio- and diastereoselective copper­(I)-catalyzed conjugate addition/enolate trapping sequence and a gold­(I)-catalyzed oxidative cyclization (intermolecular oxidant), employed for the first time in total synthesis.