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Download fileEnantioselective Total Synthesis of (−)-Dactylolide
journal contribution
posted on 2006-03-16, 00:00 authored by Ignace Louis, Natasha L. Hungerford, Edward J. Humphries, Malcolm D. McLeodThe enantioselective total synthesis of (−)-dactylolide is reported. The absolute stereochemistry of the tetrahydropyran was established by
catalytic asymmetric Jacobsen hetero-Diels−Alder reaction. The remote C19 stereocenter was introduced by a sequence of chelation-controlled
Grignard addition and Ireland−Claisen rearrangement.