jo0500939_si_002.pdf (226.74 kB)
Enantioselective Total Synthesis of (−)-Curcuquinone via Regioselective Chromium-Mediated Benzannulation
journal contribution
posted on 2005-04-29, 00:00 authored by Ana Minatti, Karl Heinz DötzA short and efficient, high-yielding enantioselective total
synthesis of the marine natural product (−)-curcuquinone
1 is reported involving a regioselective [3 + 2 + 1]-benzannulation reaction as the key step. Additionally, this strategy
allows the isolation of curcuhydroquinone monomethyl ether
9 as an intermediate of the benzannulation reaction and its
subsequent further protection toward diversified hydroquinones.