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Enantioselective Total Synthesis of (−)-Curcuquinone via Regioselective Chromium-Mediated Benzannulation

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journal contribution
posted on 29.04.2005, 00:00 by Ana Minatti, Karl Heinz Dötz
A short and efficient, high-yielding enantioselective total synthesis of the marine natural product (−)-curcuquinone 1 is reported involving a regioselective [3 + 2 + 1]-benzannulation reaction as the key step. Additionally, this strategy allows the isolation of curcuhydroquinone monomethyl ether 9 as an intermediate of the benzannulation reaction and its subsequent further protection toward diversified hydroquinones.