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Enantioselective Total Synthesis of (+)-Cassiol

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journal contribution
posted on 15.01.2009, 00:00 by Krastina V. Petrova, Justin T. Mohr, Brian M. Stoltz
An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd2(pmdba)3 and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early stage. The overall synthetic strategy involves a convergent late-stage coupling of two fragments. The synthesis features a longest linear sequence of eight steps.