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Enantioselective Synthesis of (−)-Sclerophytin A by a Stereoconvergent Epoxide Hydrolysis

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journal contribution
posted on 2010-11-24, 00:00 authored by Bin Wang, Armando P. Ramirez, Justin J. Slade, James P. Morken
The cytotoxic natural product (−)-sclerophytin A was constructed in 13 steps from geranial. Highlights from the synthesis are a stereoselective Oshima−Utimoto reaction, a Shibata−Baba indium-promoted radical cyclization, and a novel stereoconvergent epoxide hydrolysis.