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Enantioselective Synthesis of Planar Chiral Ferrocenes via Palladium-Catalyzed Direct Coupling with Arylboronic Acids

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journal contribution
posted on 09.01.2013, 00:00 by De-Wei Gao, Yan-Chao Shi, Qing Gu, Zheng-Le Zhao, Shu-Li You
Enantioselective Pd­(II)-catalyzed direct coupling of aminomethylferrocene derivatives with boronic acids was realized. With commercially available Boc-l-Val-OH as a ligand, planar-chiral ferrocenes could be synthesized in yields of 14–81% with up to 99% ee under mild conditions.