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Enantioselective Sequential Conjugate Addition−Allylation Reactions: A Concise Total Synthesis of (+)-Podophyllotoxin

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journal contribution
posted on 05.02.2009, 00:00 by Yingming Wu, Jingfeng Zhao, Jingbo Chen, Chengxue Pan, Liang Li, Hongbin Zhang
A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield.