Enantioselective Sequential Conjugate Addition−Allylation Reactions: A Concise Total Synthesis of (+)-Podophyllotoxin
journal contributionposted on 05.02.2009 by Yingming Wu, Jingfeng Zhao, Jingbo Chen, Chengxue Pan, Liang Li, Hongbin Zhang
Any type of content formally published in an academic journal, usually following a peer-review process.
A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield.