Enantioselective Rhodium Enolate Protonations. A New Methodology for the Synthesis of β2-Amino Acids
journal contributionposted on 2005-06-23, 00:00 authored by Mukund P. Sibi, Hiroto Tatamidani, Kalyani Patil
Rhodium-catalyzed conjugate addition of an aryl boronic acid to α-methylamino acrylates followed by enantioselective protonation of the oxa-π-allylrhodium intermediate provides access to aryl-substituted β2-amino acids. The impact of the different variables of the reaction on the levels of enantioselectivity has been assessed.