American Chemical Society
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Enantioselective Rhodium Enolate Protonations. A New Methodology for the Synthesis of β2-Amino Acids

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journal contribution
posted on 2005-06-23, 00:00 authored by Mukund P. Sibi, Hiroto Tatamidani, Kalyani Patil
Rhodium-catalyzed conjugate addition of an aryl boronic acid to α-methylamino acrylates followed by enantioselective protonation of the oxa-π-allylrhodium intermediate provides access to aryl-substituted β2-amino acids. The impact of the different variables of the reaction on the levels of enantioselectivity has been assessed.