American Chemical Society
ol9012469_si_002.pdf (2.27 MB)

Enantioselective Rh-Catalyzed Hydrogenation of 3-Aryl-2-phosphonomethylpropenoates by a New Class of Chiral Ferrocenyl Diphosphine Ligands

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journal contribution
posted on 2009-08-06, 00:00 authored by Dao-Yong Wang, Xiang-Ping Hu, Chuan-Jin Hou, Jun Deng, Sai-Bo Yu, Zheng-Chao Duan, Jia-Di Huang, Zhuo Zheng
A new class of chiral ferrocenyl diphosphine ligands with an imidazole ring, (Rc,SFc)-ImiFerroPhos, has been prepared from acylferrocenes through a five-step transformation and successfully applied in the Rh-catalyzed asymmetric hydrogenation of various 3-aryl-substituted 2-phosphonomethylpropenoates, in which a series of chiral 3-phosphono-2-arylmethylpropanoic acid derivatives were achieved in ee values of up to 98%.