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Enantioselective Recognition of Mandelic Acid with (R)-1,1-Bi-2-naphthol-Linked Calix[4]arene via Fluorescence and Dynamic Light Scattering

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posted on 2012-07-20, 00:00 authored by Fajun Miao, Juan Zhou, Deimei Tian, Haibing Li
A chiral 1,1-bi-2-naphthol-derived calix[4]arene (1) was synthesized via a click reaction. Fluorescence spectra and dynamic light-scattering revealed that Cu(II)–1 complexes were generated in situ and exhibited remarkable enantioselectivity toward mandelic acid. Using this dynamic light-scattering technique, the detection sensitivity was improved almost 100-fold, with a detection limit of 2.0 × 10–7 M, compared with fluorescent methods.

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