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Enantioselective Radical Hydroacylation of Enals with α‑Ketoacids Enabled by Photoredox/Amine Cocatalysis

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journal contribution
posted on 29.01.2019, 14:33 by Jia-Jia Zhao, Hong-Hao Zhang, Xu Shen, Shouyun Yu
A photoredox/amine-cocatalyzed enantioselective radical hydroacylation of enals with α-ketoacids is described. Acyl radicals generated from α-ketoacids act as the acylation reagent with the iminium ions. This strategy provides an efficient way to access synthetically challenging 1,4-dicarbonyl compounds in an enantioselective manner. The reactions of various enals with α-ketoacids show the generality and limitations of this method.