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Enantioselective β‑Protonation by a Cooperative Catalysis Strategy

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journal contribution
posted on 13.05.2015, 00:00 by Michael H. Wang, Daniel T. Cohen, C. Benjamin Schwamb, Rama K. Mishra, Karl A. Scheidt
An enantioselective N-heterocyclic carbene (NHC)-catalyzed β-protonation through the orchestration of three distinct organocatalysts has been developed. This cooperative catalyst system enhances both yield and selectivity, compared to only the NHC-catalyzed process. This new method allows for the efficient conversion of a large scope of aryl-oxobutenoates to highly enantioenriched succinate derivatives and demonstrates the benefits of combining different activation modes in organocatalysis.