ol7018532_si_003.pdf (563.32 kB)
Enantioselective Pd-Catalyzed Allylic Alkylation of Indoles by a New Class of Chiral Ferrocenyl P/S Ligands
journal contributionposted on 2007-10-11, 00:00 authored by Hong Yee Cheung, Wing-Yiu Yu, Fuk Loi Lam, Terry T.-L. Au-Yeung, Zhongyuan Zhou, Tak Hang Chan, Albert S. C. Chan
Chiral ferrocenyl heterobidentate P/S ligands bearing both central and planar chirality were prepared from (S)-Ugi's amine via a three-step modular synthesis. Through systematic screening and optimization, L8 was found to be the best ligand for Pd-catalyzed asymmetric allylic alkylation of indoles with ee's up to 96% being attained.