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Enantioselective Pd-Catalyzed Allylic Alkylation of Indoles by a New Class of Chiral Ferrocenyl P/S Ligands

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journal contribution
posted on 11.10.2007, 00:00 by Hong Yee Cheung, Wing-Yiu Yu, Fuk Loi Lam, Terry T.-L. Au-Yeung, Zhongyuan Zhou, Tak Hang Chan, Albert S. C. Chan
Chiral ferrocenyl heterobidentate P/S ligands bearing both central and planar chirality were prepared from (S)-Ugi's amine via a three-step modular synthesis. Through systematic screening and optimization, L8 was found to be the best ligand for Pd-catalyzed asymmetric allylic alkylation of indoles with ee's up to 96% being attained.