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Enantioselective Nitrone Cycloadditions of α,β-Unsaturated 2-Acyl Imidazoles Catalyzed by Bis(oxazolinyl)pyridine−Cerium(IV) Triflate Complexes

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journal contribution
posted on 2006-07-20, 00:00 authored by David A. Evans, Hyun-Ji Song, Keith R. Fandrick
Enantioselective nitrone cycloadditions with β-substituted α,β-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine−cerium(IV) triflate complexes 1 have been reported. The isoxazolidine products were efficiently transformed into densely functionalized β‘-hydroxy-β-amino acid derivatives.

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