posted on 2006-07-20, 00:00authored byDavid A. Evans, Hyun-Ji Song, Keith R. Fandrick
Enantioselective nitrone cycloadditions with β-substituted α,β-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine−cerium(IV)
triflate complexes 1 have been reported. The isoxazolidine products were efficiently transformed into densely functionalized β‘-hydroxy-β-amino acid derivatives.