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Enantioselective N‑Heterocyclic Carbene-Catalyzed Kinetic Resolution of Anilides

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journal contribution
posted on 06.09.2018, 14:20 by Jianbo Bie, Ming Lang, Jian Wang
The N-heterocyclic carbene (NHC)-catalyzed enantioselective kinetic resolution of anilides (a kind of hemiaminals) is reported. Upon exposure to the reaction in the presence of an NHC precatalyst and base, catalytic C–O bond formation occurs, providing axially chiral isoindolinones in high yields with excellent enantioselectivities.