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Enantioselective Hydrogenation of Racemic α‑Arylamino Lactones to Chiral Amino Diols with Site-Specifically Modified Chiral Spiro Iridium Catalysts

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journal contribution
posted on 2019-05-24, 00:00 authored by Xue-Song Gu, Na Yu, Xiao-Hui Yang, An-Te Zhu, Jian-Hua Xie, Qi-Lin Zhou
A protocol for highly enantioselective hydrogenation of racemic α-arylamino lactones with catalysis by site-specifically modified chiral spiro iridium complexes has been developed. With the optimized catalyst, racemic α-arylamino-γ-lactones and α-arylamino-δ-lactones could be hydrogenated to the corresponding chiral 2-amino diols with good to excellent enantioselectivities.

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