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Enantioselective Hydrogenation of β‑Ketophosphonates with Chiral Ru(II) Catalysts

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journal contribution
posted on 05.10.2012, 00:00 by Xiaoming Tao, Wanfang Li, Xin Ma, Xiaoming Li, Weizheng Fan, Lvfeng Zhu, Xiaomin Xie, Zhaoguo Zhang
Highly effective asymmetric hydrogenation of β-ketophosphonates in the presence of Ru–(S)-SunPhos as catalyst was realized; good to excellent enantioselectivities (up to 99.9% ee) and excellent diastereoselectivities (96:4) were obtained.