Enantioselective Epoxidation of β,β-Disubstituted Enamides with a Manganese Catalyst and Aqueous Hydrogen Peroxide
journal contributionposted on 18.03.2019, 18:21 by Carlota Clarasó, Laia Vicens, Alfonso Polo, Miquel Costas
Enantioselective epoxidation of β,β-disubstituted enamides with aqueous hydrogen peroxide and a novel manganese catalyst is described. Epoxidation is stereospecific and proceeds fast under mild conditions. Amides are disclosed as key functional groups to enable high enantioselectivity.