posted on 2018-07-10, 18:20authored byMinyan Wang, Xinghui Pu, Yunfei Zhao, Panpan Wang, Zexian Li, Chendan Zhu, Zhuangzhi Shi
A copper-catalyzed
system has been introduced for the enantioselective
defluoroalkylation of linear 1-(trifluoromethyl)alkenes through C–F
activation to synthesize various gem-difluoroalkenes
as carbonyl mimics. For the first time, arylboronate-activated alkyl
Grignard reagents were uncovered in this cross-coupling reaction.
Mechanistic studies confirmed that the tetraorganoborate complexes
generated in situ were the key reactive species for this transformation.