American Chemical Society
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Enantioselective Construction of Carbobicyclic Scaffolds

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journal contribution
posted on 2004-11-03, 00:00 authored by Douglass F. Taber, Yigang He, Ming Xu
Allylic and benzylic Grignard reagents smoothly open phenylalkynyl-activated cyclic trisubstituted epoxides at the more substituted carbon atom to give secondary alcohols with a chiral quaternary center. These alcohols are good substrates for the construction of enantiomerically pure carbobicyclic scaffolds through intramolecular alkylation.