ja5b06010_si_001.pdf (5.28 MB)

Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex

Download (5.28 MB)
journal contribution
posted on 05.08.2015, 00:00 by Haohua Huo, Chuanyong Wang, Klaus Harms, Eric Meggers
An enantioselective, catalytic trichloromethylation of 2-acyl imidazoles and 2-acylpyridines is reported. Several products are formed with enantiomeric excess of ≥99%. In this system, a chiral iridium complex serves a dual function, as a catalytically active chiral Lewis acid and simultaneously as a precursor for an in situ assembled visible-light-triggered photoredox catalyst.