posted on 2017-02-16, 00:00authored byXiaohong Chen, Shujing Yang, Helong Li, Bo Wang, Guoyong Song
The asymmetric C–H
annulation of O-pivaloyl
1-indolehydroxamic acid with donor/acceptor diazo compounds has been
achieved for the first time, to the best of our knowledge, by using
a rhodium catalyst embedded in a chiral binaphthyl backbone. This
protocol constitutes a straightforward route for the synthesis of
a new family of 1,2-dihydro-3H-imidazo[1,5-a]indol-3-one derivatives having a quaternary carbon stereocenter
in high yields and excellent enantioselectivity (up to 98:2 er).