posted on 2021-12-21, 18:03authored byXuemei Wang, Liang Zhou, Hongkui Zhang, Xiaoyu Ren, Guowei Gao, Tianli Wang
A highly
enantioselective γ-addition-driven cascade of β,γ-unsaturated
carbonyl compounds by bifunctional ion-pair catalysis has been developed.
With this protocol, a range of functionalized chiral 1,3-dioxolochroman
derivatives were prepared in high yields with superior stereoselectivities
(>99% ee and >20:1 dr). The
utility
of this method was demonstrated by one-pot synthesis, scaled-up preparation,
and facile transformation. Moreover, mechanistic investigations provided
insights into the reaction pathway and the origin of chiral induction.