ol2033459_si_001.pdf (2.62 MB)

Enantioselective Acylation of 1,2- and 1,3-Diols Catalyzed by Aminophosphinite Derivatives of (1S,2R)-1-Amino-2-indanol

Download (2.62 MB)
journal contribution
posted on 22.02.2016, 07:04 by Hiroyuki Aida, Kouhei Mori, Yasuyuki Yamaguchi, Shinya Mizuta, Tomomi Moriyama, Iwao Yamamoto, Tetsuya Fujimoto
A phosphinite derivative that can be easily prepared in two steps from commercially available aminoindanol was found to be an effective catalyst for enantioselective acylation of diols. For the asymmetric desymmetrization of meso-1,2-diols, the corresponding monoester was obtained in up to 95% ee from the reaction in the presence of 5 mol % catalyst.