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Enantiopure Peptide-Functionalized Metal–Organic Frameworks

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journal contribution
posted on 29.07.2015, 00:00 by Jonathan Bonnefoy, Alexandre Legrand, Elsje Alessandra Quadrelli, Jérôme Canivet, David Farrusseng
We present herein the first example of metal–organic frameworks postfunctionalized with peptides. Our microwave-assisted postsynthetic modification method yields enantiopure peptides anchored inside MOF cavities. Al-MIL-101-NH2, In-MIL-68-NH2, and Zr-UiO-66-NH2 were chosen as starting platforms. A single amino acid and various oligopeptides are grafted with yields up to 60% after a 30 min microwave-assisted coupling-deprotection sequence. This allows efficient preparation of a library of functional hybrid solids for molecular recognition applications such as sensing, separation, or asymmetric catalysis, as demonstrated here for the chiral aldol reaction.