Enamide-Benzyne-[2 + 2] Cycloaddition: Stereoselective Tandem [2 + 2]−Pericyclic Ring-Opening−Intramolecular N-Tethered [4 + 2] Cycloadditions

Feltenberger, John B.; Hayashi, Ryuji; Tang, Yu; S. C. Babiash, Eric; Hsung, Richard P.

doi:10.1021/ol901434g.s002

Enamide-Benzyne-[2 + 2] Cycloaddition: Stereoselective Tandem [2 + 2]−Pericyclic Ring-Opening−Intramolecular N-Tethered [4 + 2] Cycloadditions

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posted on 2009-08-20, 00:00 authored by John B. Feltenberger, Ryuji Hayashi, Yu Tang, Eric S. C. Babiash, Richard P. Hsung

Benzyne-[2 + 2] cycloadditions with enamides are described. This effort led to the development of a highly stereoselective tandem [2 + 2] cycloaddition−pericyclic ring-opening−intramolecular-N-tethered-[4 + 2] cycloaddition for rapid assembly of nitrogen heterocycles.

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Enamide-Benzyne-[2 + 2] Cycloaddition: Stereoselective Tandem [2 + 2]−Pericyclic Ring-Opening−Intramolecular N-Tethered [4 + 2] Cycloadditions

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