Enabling the Selective Detection of Endocrine-Disrupting Chemicals via Molecularly Surface-Imprinted “Coffee Rings”
journal contributionposted on 22.02.2021, 18:36 by Jihye Lee, Jin Chul Yang, Saifullah Lone, Woon Ik Park, Zhiqun Lin, Jinyoung Park, Suck Won Hong
Molecularly imprinted polymers (MIPs) represent an intriguing class of synthetic materials that can selectively recognize and bind chemical or biological molecules in a variety of value-added applications in sensors, catalysis, drug delivery, antibodies, and receptors. In this context, many advanced methods of implementing functional MIP materials have been actively studied. Herein, we report a robust strategy to produce highly ordered arrays of surface-imprinted polymer patterns with unprecedented regularity for MIP-based sensor platform, which involves the controlled evaporative self-assembly process of MIP precursor solution in a confined geometry consisting of a spherical lens on a flat Si substrate (i.e., sphere-on-flat geometry) to synergistically utilize the “coffee-ring” effect and repetitive stick–slip motions of the three-phase contact line simply by solvent evaporation. Highly ordered arrays of the ring-patterned MIP films are then polymerized under UV irradiation to achieve semi-interpenetrating polymer networks. The extraction of templated target molecules from the surface-imprinted ring-patterned MIP films leaves behind copious cavities for the recognizable specific “memory sites” to efficiently detect small molecules. As a result, the elaborated surface structuring effect, sensitivity, and specific selectivity of the coffee-ring-based MIP sensors are scrutinized by capitalizing on an endocrine-disrupting chemical, 2,4-dichlorophenoxyacetic acid (2,4-D), as an example. Clearly, the evaporative self-assembly of nonvolatile solutes in a confined geometry renders the creation of familiar yet ordered coffee-ring-like patterns for a wide range of applications, including sensors, scaffolds for cell motility, templates, substrates for neuron guidance, etc., thereby dispensing with the need of multistep lithography techniques and external fields.
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self-assembly processcoffee-ring-like patternstemplated target moleculessurface-imprinted ring-patterned MI...MIP-based sensor platformring-patterned MIP filmsneuron guidanceEndocrine-Disrupting Chemicalsnonvolatile solutescell motilitythree-phase contact linearraysemi-interpenetrating polymer networksmultistep lithography techniquesMIP materialsbind chemicalSelective DetectionMolecularlycoffee-ring-based MIP sensorsapplicationSi substrateMIP precursor solutionendocrine-disrupting chemicalsurface-imprinted polymer patternsdrug deliveryUV irradiation