posted on 2021-11-17, 14:34authored byNiginia Borlinghaus, Barbara Schönfeld, Stephanie Heitz, Johanna Klee, Stella Vukelić, Wilfried M. Braje, Anais Jolit
Compressed tablets
containing a mixture of a photocatalyst, a nickel
catalyst, an inorganic base, and an inert excipient are employed as
a fast, safe, and user-friendly chemical delivery system for two different
metallophotoredox-catalyzed reactions. This delivery method simplifies
the preparation of compound libraries using photoredox chemistry in
a parallel setting. The reagent tablets were successfully applied
to late-stage functionalization of drug-like intermediates. These
tablets can be prepared with various reagents and catalysts in different
sizes and be stored on the bench thanks to blister packaging.