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Emulsifying Properties of an Homologous Series of Medium- and Long-Chain d‑Maltotriose Esters and their Impacts on the Viabilities of Selected Cell Lines
journal contribution
posted on 2020-08-06, 11:38 authored by Jian-Peng Zhu, Ya-Ru Ma, Yinglai Teng, Jing Chen, Martin G. Banwell, Ping LanThe development of functional as
well as nutritional surfactants
for the food industry remains a matter of great interest. In the present
study, a series of 6″-O-acylmaltotriose monoesters
bearing alkyl side chains of 10–18 carbons was prepared by
enzymatic means. The emulsions derived from those monoesters incorporating
palmitoyl, stearoyl, and oleoyl side chains generally displayed advantageous
shelf-lives, superior resistance to environmental variations, and
more favorable droplet size distributions as well as stronger cytotoxic
effects against various cancer cell lines. Ester 6 was
shown to significantly inhibit the proliferation of MCF-7 breast cancer
cells by inducing G1 phase arrest. Specifically, the levels of the
G1 phase-related markers cyclin D1 and cyclin E as well as the cycle-dependent
kinase 4 were suppressed by this particular ester. This study thus
reveals that maltotriose esters can not only serve as novel functional
food emulsifiers but also act, in vitro, as notable
cytotoxic agents through a well-defined mechanism-of-action.
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stearoylalkyl side chainsresistanceHomologous Seriesemulsionoleoyl side chainssurfactantMCF -7 breast cancer cellscyclin EEster 6cycle-dependent kinase 4ImpactEmulsifying PropertiesseriesMediumproliferationpalmitoylmechanism-of-actionacylmaltotriose monoestersmaltotriose estersSelected Cell LinesG 1 phase-related markers cyclin D 1food industrymattercancer cell linescytotoxic agentsfood emulsifiersdroplet size distributionscytotoxic effectsvariationLong-Chainshelf-liveViabilitieG 1 phase arrest
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