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Eleganketal A, a Highly Oxygenated Dibenzospiroketal from the Marine-Derived Fungus Spicaria elegans KLA03

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journal contribution
posted on 25.07.2014, 00:00 by Yepeng Luan, Hongjuan Wei, Zhenpei Zhang, Qian Che, Yankai Liu, Tianjiao Zhu, Attila Mándi, Tibor Kurtán, Qianqun Gu, Dehai Li
Eleganketal A (1), a naturally occurring aromatic polyketide possessing a rare highly oxygenated spiro­[isobenzofuran-1,3′-isochroman] ring system, was isolated from the fungus Spicaria elegans KLA03 by culturing it in a modified mannitol-based medium. The structure of 1 including the absolute configuration was determined by combining spectroscopic analysis, synthesis of the racemic permethylated analogue, chiral-phase HPLC separation, and TDDFT-ECD analysis.