American Chemical Society
ol8b00165_si_001.pdf (2.19 MB)

Electrosynthesis of Trisubstituted 2‑Oxazolines via Dehydrogenative Cyclization of β‑Amino Arylketones

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journal contribution
posted on 2018-04-17, 19:15 authored by Huiqiao Wang, Jinjin Zhang, Jiajing Tan, Lilan Xin, Yaping Li, Sheng Zhang, Kun Xu
An electrochemically intramolecular functionalization of C­(sp3)–H bonds with masked oxygen nucleophiles was developed. With KI as the catalyst and electrolyte, diverse trisubstituted 2-oxazolines were constructed in good to excellent yields. This newly developed electrochemical dehydrogenative approach features external oxidant-free and additive-free conditions.