Electrooxidative Amination of sp2 C–H Bonds: Coupling of Amines with Aryl Amides via Copper Catalysis
journal contributionposted on 2019-02-20, 15:03 authored by Subban Kathiravan, Subramanian Suriyanarayanan, Ian A. Nicholls
Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C–H activation for sp2 C–N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C–H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H2 as the sole and benign byproduct.
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reaction conditionsDescribedcross-coupling chemistrycopper catalysisElectrooxidative AminationH 2Copper Catalysis Metal-catalyzed cross-coupling reactionsliberationatom-and step-economical mannertransformationsynthesiscombinationactivationaminationAryl AmidesBondchallengespbyproductelectrocatalysiAminearylformationbond