Electrooxidative Amination of sp² C–H Bonds: Coupling of Amines with Aryl Amides via Copper Catalysis

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C–H activation for sp² C–N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C–H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H₂ as the sole and benign byproduct.