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Electrooxidative Amination of sp2 C–H Bonds: Coupling of Amines with Aryl Amides via Copper Catalysis
journal contribution
posted on 2019-02-20, 15:03 authored by Subban Kathiravan, Subramanian Suriyanarayanan, Ian A. NichollsMetal-catalyzed cross-coupling reactions
are among the most important
transformations in organic synthesis. However, the use of C–H
activation for sp2 C–N bond formation remains one
of the major challenges in the field of cross-coupling chemistry.
Described herein is the first example of the synergistic combination
of copper catalysis and electrocatalysis for aryl C–H amination
under mild reaction conditions in an atom-and step-economical manner
with the liberation of H2 as the sole and benign byproduct.
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Keywords
reaction conditionsDescribedcross-coupling chemistrycopper catalysisElectrooxidative AminationH 2Copper Catalysis Metal-catalyzed cross-coupling reactionsliberationatom-and step-economical mannertransformationsynthesiscombinationactivationaminationAryl AmidesBondchallengespbyproductelectrocatalysiAminearylformationbond