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Electrochemistry of DNA Monolayers Modified With a Perylenediimide Base Surrogate

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journal contribution
posted on 18.12.2014, 00:00 by Chris H. Wohlgamuth, Marc A. McWilliams, Amir Mazaheripour, Anthony M. Burke, Kuo-Yao Lin, Linh Doan, Jason D. Slinker, Alon A. Gorodetsky
Electrochemistry of self-assembled DNA monolayers represents an attractive strategy for understanding the intrinsic properties of DNA and for developing DNA-based sensors. Thus, there is much interest in the discovery and characterization of new redox-active probes for application in DNA-based technologies. Herein, we report a detailed study of the electrochemical properties of a perylene-3,4,9,10-tetracarboxylic diimide base surrogate, when incorporated at various positions within a DNA monolayer. We demonstrate that the redox chemistry of this perylenediimide probe is mediated by the DNA base pair stack, dependent on its location within the DNA monolayer, and activated thermally. The electrochemical features and general synthetic flexibility of the perylenediimide base surrogate appear favorable for assays that leverage DNA-mediated charge transport.

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