American Chemical Society
ol3c03901_si_001.pdf (9.82 MB)

Electrochemical Fluorination Functionalization of gem-Difluoroalkenes with CsF as a Fluorine Source: Access to Fluoroalkyl Building Blocks

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journal contribution
posted on 2023-12-29, 15:37 authored by Linzi Wen, Ziyan Zou, Naifu Zhou, Chengbo Sun, Peixu Xie, Pengju Feng
Using easily handled CsF as a fluorine source, an electrochemically metal-free protocol for chemo- and regioselective synthesis of various types of long-chain perfluoroalkyl aromatics with gem-difluoroalkene as a substrate and an alcohol or azole as an additional nucleophile was developed. The eletrochemical transformation could tolerate several functional groups, such as halogens, cyanos, benzyls, and heterocycles, and is amenable to gram-scale. The application of this electrochemical method in radiofluorination was also tested.