Electrochemical-Promoted Nickel-Catalyzed Oxidative Fluoroalkylation of Aryl Iodides
journal contributionposted on 14.10.2021, 02:43 by Zhenlei Zou, Heyin Li, Mengjun Huang, Weigang Zhang, Sanjun Zhi, Yi Wang, Yi Pan
This work describes a general strategy for metal-catalyzed cross-coupling of fluoroalkyl radicals with aryl halides under electrochemical conditions. The contradiction between anodic oxidation of fluoroalkyl sulfinates and cathodic reduction of low-valent nickel catalysts can be well addressed by paired electrolysis, allowing for direct introduction of fluorinated functionalities into aromatic systems.
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valent nickel catalystscatalyzed oxidative fluoroalkylationpromoted nickelcatalyzed crosswork describeswell addressedpaired electrolysisgeneral strategyfluoroalkyl sulfinatesfluoroalkyl radicalsfluorinated functionalitiesdirect introductioncathodic reductionaryl iodidesaryl halidesaromatic systemsanodic oxidation