American Chemical Society
ol301240g_si_001.pdf (1.6 MB)

Efficient and Highly Aldehyde Selective Wacker Oxidation

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journal contribution
posted on 2012-07-06, 00:00 authored by Peili Teo, Zachary K. Wickens, Guangbin Dong, Robert H. Grubbs
A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl2(MeCN)2, 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates.