Efficient and Highly Aldehyde Selective Wacker Oxidation

Teo, Peili; Wickens, Zachary K.; Dong, Guangbin; Grubbs, Robert H.

doi:10.1021/ol301240g.s001

ol301240g_si_001.pdf (1.6 MB)

Efficient and Highly Aldehyde Selective Wacker Oxidation

journal contribution

posted on 2012-07-06, 00:00 authored by Peili Teo, Zachary K. Wickens, Guangbin Dong, Robert H. Grubbs

A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl₂(MeCN)₂, 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates.